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Case Reports and Review 

Primary Neuroendocrine Breast Tumors: Case Reports and Review of the Literature

Gomez-Hidalgo NR1*, Mohamed Ahmed E2, Gomez M1, Martin-Ondarza C1, De Dios E1

Primary neuroendocrine carcinoma of the breast (NCB) is a rare entity. This type of tumor is defined as a breast carcinoma where more than 50% of the tumor cells express neuroendocrine markers, including the chromogranin, synaptophysin and neuron specific enolase. The incidence accounts for up to 5% of all breast tumors and approximately 1% of all neuroendocrine tumors; the most important problem is the lack of standardized treatment. Therefore, we described our cases of our single institution and the treatment undergone by these patients.

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